Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.

Full Abstract

Women with estrogen receptor (ER) positive breast cancer, who are treated with the ER blocker, tamoxifen, have an increased risk of depression. Trilostane, a 3b-hydroxysteroid dehydrogenase inhibitor, is now being used to treat tamoxifen-insensitive breast cancer. In-vitro assays show that trilostane may have actions through ERb. Results of in-vivo research shows that actions at ERb may underline some antidepressant effects of estrogen. We hypothesized that trilostane may exert antidepressive effects in the forced swim in part due to actions through ERb. Trilostane (25 mg/kg, intraperitoneally), compared with vehicle, had significant antidepressant-like effects but only when administered to wild-type, not ERb knockout, mice. Thus, actions of trilostane through ERb may underlie some of its antidepressant-like effects.

Author information

Author/s: Koonce, Carolyn J (CJ); Walf, Alicia A (AA); Frye, Cheryl A (CA);

Affiliation: Department of aPsychology, University at Albany-SUNY, Albany, New York 12222, USA.

Grants: MH06769801 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2009-Aug; vol 20 (issue 12) : pp 1047-50

Dates: Created 2009/07/13; Completed 2009/09/29;

PMID: 19593916, status: MEDLINE (last retrieval date: 9/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Antidepressive Agents - pharmacology
Corticosterone - blood
Depression - drug therapy; metabolism
Dihydrotestosterone - analogs & derivatives; pharmacology
Estrogen Receptor beta - genetics; metabolism
Hippocampus - metabolism
Male

Associated Chemicals: Antidepressive Agents (0) ; Estrogen Receptor beta (0) ; Pregnanolone (128-20-1) ; trilostane (13647-35-3) ; Corticosterone (50-22-6) ; Dihydrotestosterone (521-18-6)

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