Research article summary (published 29 Sep 2009):

High bone matrix turnover predicts blood levels of lead among perimenopausal women.

Full Abstract

Skeletal bone is the primary endogenous source of lead in circulating blood, particularly under conditions of accelerated bone turnover and mineral loss, such as pregnancy and postmenopausal osteoporosis. We studied the influence of bone turnover rate on the release of lead from bone in 1225 female farmers from 5 districts in Japan. We collected peripheral blood and urine samples and medical nutritional information, and measured forearm bone mineral density (BMD). We found that blood lead levels in perimenopausal women were highest among all groups studied. Analysis of data for subjects grouped by level of markers of bone metabolism suggested that, in perimenopausal women, blood lead levels were higher in groups with high levels of N-telopeptide cross-linked collagen type I (NTx) and high levels of bone-specific alkaline phosphates (BALP) or osteocalcin (OC) compared with groups with low NTx and low BALP or OC levels. Linear multivariate models showed that markers of bone turnover were significantly positively related to blood lead levels. These results provide evidence that high bone turnover rates increase the release of lead stored in bone into the circulation. It is likely that markers of bone metabolism can be used to predict blood lead levels.

Author information

Author/s: Machida, Munehito (M); Sun, Su-Ju (SJ); Oguma, Etsuko (E); Kayama, Fujio (F);

Affiliation: Division of Environmental Medicine, Center for Community Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Environmental research (Environ Res), published in United States. (Language: eng)

Reference: 2009-Oct; vol 109 (issue 7) : pp 880-6

Dates: Created 2009/09/14; Completed 2009/10/01;

PMID: 19595303, status: MEDLINE (last retrieval date: 10/1/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Alkaline Phosphatase - blood Bone Density - physiology Bone Remodeling - physiology Bone and Bones - metabolism Collagen Type I - urine Cross-Sectional Studies Female Forearm Humans

Humans Japan Lead - blood Luteinizing Hormone - blood Menopause - blood; urine Middle Aged Multivariate Analysis Osteocalcin - blood Peptides - urine Questionnaires Statistics, Nonparametric

Associated Chemicals: Collagen Type I (0) ; Peptides (0) ; collagen type I trimeric cross-linked peptide (0) ; Osteocalcin (104982-03-8) ; Lead (7439-92-1) ; Luteinizing Hormone (9002-67-9) ; Alkaline Phosphatase (EC 3.1.3.1)

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