Rapid response to paroxetine is associated with plasma paroxetine levels at 4 but not 8 weeks of treatment, and is independent of serotonin transporter promoter polymorphism in Japanese depressed patients.

Full Abstract

In the present study, we investigated the relationship between the serotonin transporter gene linked polymorphic regions (5-HTTLPR) or plasma paroxetine levels and clinical response to paroxetine in depressed patients. Sixty patients who met the DSM-IV criteria for major depressive disorder were enrolled in the study. Twenty-two were male and 38 were female, with ages ranging from 25 to 71 (mean +/- SD = 42 +/- 16) years. The clinical improvement of patients was assessed using the Hamilton rating scale for depression (Ham-D) before and every week after paroxetine administration. According to the data reported previously, patients with an at least 50% decrease in their Ham-D score were classified as responders. The results showed that the plasma paroxetine levels at 4 weeks were significantly higher in responders (rapid responders) than in nonresponders. On the other hand, no significant associations were found between the L genotype (L/L, L/S) or S genotype (S/S) and the response rates either at 4 weeks or 8 weeks. These results suggest that patients with higher plasma levels at 4 weeks might respond rapidly to paroxetine treatment, but the final response rate at 8 weeks will be independent of the plasma paroxetine levels and the 5-HTTLPR L/S genotype. 2009 John Wiley & Sons, Ltd.

Author information

Author/s: Yoshimura, Reiji (R); Umene-Nakano, Wakako (W); Suzuki, Akihito (A); Ueda, Nobuhisa (N); Miyamoto, Kyoko (K); Ikenouchi-Sugita, Atsuko (A); Hori, Hikaru (H); Otani, Koichi (K); Nakamura, Jun (J);

Affiliation: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan. yoshi621(-atsign-)med.uoeh-u.ac.jp

Journal and publication information

Publication Type: Clinical Trial; Journal Article

Journal: Human psychopharmacology (Hum Psychopharmacol), published in England. (Language: eng)

Reference: 2009-Aug; vol 24 (issue 6) : pp 489-94

Dates: Created 2009/08/11; Completed 2009/10/20;

PMID: 19606452, status: MEDLINE (last retrieval date: 10/20/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Depressive Disorder, Major - drug therapy; genetics
Female
Genotype
Humans
Japan

Male
Middle Aged
Paroxetine - blood; therapeutic use
Psychiatric Status Rating Scales
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Uptake Inhibitors - blood; therapeutic use
Time Factors

Associated Chemicals: SLC6A4 protein, human (0) ; Serotonin Plasma Membrane Transport Proteins (0) ; Serotonin Uptake Inhibitors (0) ; Paroxetine (61869-08-7)

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