Research article summary (published 13 Nov 2009):

Clinical and biological significance of CXCR5 expressed by prostate cancer specimens and cell lines.

Full Abstract

Chemokines and chemokine receptors have been shown to be involved in metastatic process of prostate cancer (PCa). In this study, we show primary PCa tissues and cell lines (LNCaP and PC3) express CXCR5, a specific chemokine receptor for CXCL13. Expression of CXCR5 was significantly higher (p < 0.001) in PCa cases than compared to normal match (NM) tissues. CXCR5 intensity correlated (R(2) = 0.97) with Gleason score. While prostate tumor tissues with Gleason scores >or= 7, displayed predominantly nuclear CXCR5 expression patterns, PCa specimens with Gleason scores

Author information

Author/s: Singh, Shailesh (S); Singh, Rajesh (R); Singh, Udai P (UP); Rai, Shesh N (SN); Novakovic, Kristian R (KR); Chung, Leland W K (LW); Didier, Peter J (PJ); Grizzle, William E (WE); Lillard, James W (JW);

Affiliation: Department of Microbiology and Immunology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.

Grants: AI057808 (Agency:NIAID NIH HHS) ; CA086359 (Agency:NCI NIH HHS) ; CA092078 (Agency:NCI NIH HHS) ; DK58967 (Agency:NIDDK NIH HHS) ; GM08248 (Agency:NIGMS NIH HHS) ; GM09248 (Agency:NIGMS NIH HHS) ; MD00525 (Agency:NCMHD NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2009-Nov; vol 125 (issue 10) : pp 2288-95

Dates: Created 2009/09/28; Completed 2009/11/05;

PMID: 19610059, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cell Adhesion Cell Movement Chemokine CXCL13 - genetics; metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Humans Immunoenzyme Techniques Male Matrix Metalloproteinases - genetics; metabolism

Neoplasm Invasiveness Neoplasm Staging Prostate - metabolism; pathology Prostatic Hyperplasia - genetics; metabolism; pathology Prostatic Neoplasms - genetics; metabolism; pathology RNA, Messenger - genetics; metabolism Receptors, CXCR5 - genetics; metabolism Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured

Associated Chemicals: CXCL13 protein, human (0) ; CXCR5 protein, human (0) ; Chemokine CXCL13 (0) ; RNA, Messenger (0) ; Receptors, CXCR5 (0) ; Matrix Metalloproteinases (EC 3.4.24.-)

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