Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels.

Full Abstract

A longitudinal cohort study was conducted in Helicobactor pylori-infected middle-aged Japanese males to evaluate the preventive effects of H. pylori eradication on the development of gastric cancer according to the extent of chronic atrophic gastritis (CAG). The extent of CAG was monitored by baseline serum pepsinogen (PG) levels. We followed 3,656 subjects with persistent H. pylori infection and 473 subjects with successful H. pylori eradication for cancer development for a mean (SD) of 9.3 (0.7) years. Groups with and without extensive CAG were categorized based on PG test-positive criteria to detect extensive CAG of PG I

Author information

Author/s: Yanaoka, Kimihiko (K); Oka, Masashi (M); Ohata, Hiroshi (H); Yoshimura, Noriko (N); Deguchi, Hisanobu (H); Mukoubayashi, Chizu (C); Enomoto, Shotaro (S); Inoue, Izumi (I); Iguchi, Mikitaka (M); Maekita, Takao (T); Ueda, Kazuki (K); Utsunomiya, Hirotoshi (H); Tamai, Hideyuki (H); Fujishiro, Mitsuhiro (M); Iwane, Masataka (M); Takeshita, Tatsuya (T); Mohara, Osamu (O); Ichinose, Masao (M);

Affiliation: Department of Gastroenterology, School of Medicine, Wakayama Medical University, Wakayama-city, Wakayama, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2009-Dec; vol 125 (issue 11) : pp 2697-703

Dates: Created 2009/10/05; Completed 2009/11/06;

PMID: 19610064, status: MEDLINE (last retrieval date: 11/6/2009, IMS Date: )

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