Growth patterns in children with intrauterine growth retardation and their correlation to neurocognitive development.

Full Abstract

The relationship between somatic growth and neurocognitive outcome was studied in a cohort of 136 children with intrauterine growth retardation. The children were followed up from birth to 9 to 10 years of age by annual measurements of growth parameters, neurodevelopmental evaluations, and IQ. The rate of catch-up for height between 1 and 2 years of age was significantly higher than the catch-up for weight (P < .001). The cognitive outcome at 9 to 10 years correlated with head circumference at all ages. The neurodevelopmental outcome at 9 to 10 years correlated with weight at all ages. Correlation with head circumference was more significant with IQ, while with weight it was stronger with the neurodevelopmental score. Height at 1 year was a significant predictor for IQ and neurodevelopmental outcome at 9 to 10 years. These findings are of distinct importance for prediction of subsequent neurodevelopmental outcome in children with intrauterine growth retardation.

Author information

Author/s: Fattal-Valevski, Aviva (A); Toledano-Alhadef, Hagit (H); Leitner, Yael (Y); Geva, Ronny (R); Eshel, Rina (R); Harel, Shaul (S);

Affiliation: Institute for Child Development and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel. afatal(-atsign-)post.tau.ac.il

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of child neurology (J Child Neurol), published in United States. (Language: eng)

Reference: 2009-Jul; vol 24 (issue 7) : pp 846-51

Dates: Created 2009/07/20; Completed 2009/10/06;

PMID: 19617460, status: MEDLINE (last retrieval date: 10/6/2009, IMS Date: )

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