Research article summary (published 30 May 2009):

Effects of the cannabinoid receptor ligands on anxiety-related effects of d-amphetamine and nicotine in the mouse elevated plus maze test.

Full Abstract

The purpose of the experiments was to examine the anxiety-related effects of d-amphetamine and nicotine, and the possible involvement of the endocannabinoid system. D-amphetamine (2 mg/kg, ip) was administered acutely or daily for 8 days. On the 9th day, mice were challenged with d-amphetamine (2 mg/kg, ip) or nicotine (0.1 mg/kg, sc), and were tested in the elevated plus maze. Additionally, a distinct group of mice was pretreated with an acute (0.1 mg/kg,sc) or subchronic nicotine (6 days), and subjected to nicotine (0.1 mg/kg, sc) or d-amphetamine (2 mg/kg, ip) challenge on the 7th day. The cannabinoid receptor ligands, WIN 55,212-2, a non-selective cannabinoid receptor agonist (0.25; 0.5 and 1 mg/kg, ip) and rimonabant, a CB1 cannabinoid receptor antagonist (0.25; 0.5; 1 and 2 mg/kg, ip) were injected prior to each injection of saline or acute and subchronic d-amphetamine or nicotine. We observed that acute anxiogenic and subchronic anxiolytic effects of both psychostimulants as well as the development of full cross-tolerance to their anxiogenic effects were dose-dependently blunted by ineffective doses of WIN 55,212-2 (0.25 and 0.5 mg/kg) and rimonabant (0.5 and 1 mg/kg). These results provide evidence that the endogenous cannabinoid system is involved in the anxiety-related responses to d-amphetamine and/or nicotine.

Author information

Author/s: Biala, G (G); Kruk, M (M); Budzynska, B (B);

Affiliation: Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland. grazyna.biala(-atsign-)umlub.pl

Journal and publication information

Publication Type: Journal Article

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society (J Physiol Pharmacol), published in Poland. (Language: eng)

Reference: 2009-Jun; vol 60 (issue 2) : pp 113-22

Dates: Created 2009/07/20; Completed 2009/10/22;

PMID: 19617654, status: MEDLINE (last retrieval date: 10/22/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Anxiety - metabolism; psychology Benzoxazines - pharmacology Central Nervous System Stimulants - administration & dosage; pharmacology Dextroamphetamine - administration & dosage; pharmacology Dose-Response Relationship, Drug Drug Interactions Ligands Male

Maze Learning - drug effects; physiology Mice Morpholines - pharmacology Naphthalenes - pharmacology Nicotine - administration & dosage; pharmacology Piperidines - pharmacology Pyrazoles - pharmacology Receptor, Cannabinoid, CB1 - antagonists & inhibitors; physiology Receptors, Cannabinoid - agonists; physiology

Associated Chemicals: Benzoxazines (0) ; Central Nervous System Stimulants (0) ; Ligands (0) ; Morpholines (0) ; Naphthalenes (0) ; Piperidines (0) ; Pyrazoles (0) ; Receptor, Cannabinoid, CB1 (0) ; Receptors, Cannabinoid (0) ; Win 55212-2 (134959-51-6) ; rimonabant (158681-13-1) ; Dextroamphetamine (51-64-9) ; Nicotine (54-11-5)

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