WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

Full Abstract

WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

Author information

Author/s: Noronha, Suzie A (SA); Farrar, Jason E (JE); Alonzo, Todd A (TA); Gerbing, Robert B (RB); Lacayo, Norman J (NJ); Dahl, Gary V (GV); Ravindranath, Yaddanapudi (Y); Arceci, Robert J (RJ); Loeb, David M (DM);

Affiliation: Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

Grants: 5T32CA060441-15 (Agency:NCI NIH HHS) ; CA120535 (Agency:NCI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Pediatric blood & cancer (Pediatr Blood Cancer), published in United States. (Language: eng)

Reference: 2009-Dec; vol 53 (issue 6) : pp 1136-9

Dates: Created 2009/09/16; Completed 2009/10/13;

PMID: 19618455, status: MEDLINE (last retrieval date: 10/13/2009, IMS Date: )

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