Research article summary (published 29 Jun 2009):

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

Full Abstract

Wnt/beta-catenin and NF-kappaB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/beta-catenin signaling requires epithelial beta-catenin activity. We find that Wnt/beta-catenin signaling is absolutely required for NF-kappaB activation, and that Edar is a direct Wnt target gene. Wnt/beta-catenin signaling is initially activated independently of EDA/EDAR/NF-kappaB activity in primary hair follicle primordia. However, Eda/Edar/NF-kappaB signaling is required to refine the pattern of Wnt/beta-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-kappaB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-kappaB target. These data reveal a complex interplay and interdependence of Wnt/beta-catenin and EDA/EDAR/NF-kappaB signaling pathways in initiation and maintenance of primary hair follicle placodes.

Author information

Author/s: Zhang, Yuhang (Y); Tomann, Philip (P); Andl, Thomas (T); Gallant, Natalie M (NM); Huelsken, Joerg (J); Jerchow, Boris (B); Birchmeier, Walter (W); Paus, Ralf (R); Piccolo, Stefano (S); Mikkola, Marja L (ML); Morrisey, Edward E (EE); Overbeek, Paul A (PA); Scheidereit, Claus (C); Millar, Sarah E (SE); Schmidt-Ullrich, Ruth (R);

Affiliation: Departments of Dermatology and Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Grants: R01-AR47709-09 (Agency:NIAMS NIH HHS) ; R01-DE015342 (Agency:NIDCR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Developmental cell (Dev Cell), published in United States. (Language: eng)

Reference: 2009-Jul; vol 17 (issue 1) : pp 49-61

Dates: Created 2009/07/21; Completed 2009/09/01;

PMID: 19619491, status: MEDLINE (last retrieved date: 9/1/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Carrier Proteins - genetics; metabolism Cell Differentiation - physiology Ectoderm - cytology; metabolism Ectodysplasins - genetics; metabolism Embryo, Mammalian - anatomy & histology; physiology Female Gene Expression Regulation, Developmental Genes, Reporter Hair Follicle - cytology; embryology; physiology

Hair Follicle - cytology; embryology; physiology Mice Mice, Transgenic NF-kappa B - genetics; metabolism Pregnancy Receptors, Ectodysplasin - genetics; metabolism Signal Transduction - physiology Skin - cytology; embryology; metabolism Wnt Proteins - genetics; metabolism beta Catenin - genetics; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Carrier Proteins (0) ; Ectodysplasins (0) ; Eda protein, mouse (0) ; NF-kappa B (0) ; Receptors, Ectodysplasin (0) ; Wnt Proteins (0) ; beta Catenin (0) ; noggin protein (148294-77-3)

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