Research article summary (published 29 Sep 2009):

Function and phenotype of microglia are determined by toll-like receptor 2/toll-like receptor 4 activation sequence.

Full Abstract

Toll-like receptors (TLRs) initiate and maintain host defenses. These receptors play important roles in innate immunity and in various diseases. Different TLRs bind to diverse ligands that trigger distinct protein expression patterns. Few studies have focused on the interaction between different TLRs. We found that TLR2 priming downregulates TLR4 transcription, and expression of TLR4 activation induced major histocompatibility complex II (MHC II), adhesion molecule intercellular adhesion molecule-1 (ICAM-1), phagocytosis marker CD11b/CD18, and Fcgamma receptor (FcgammaR) expression. In contrast, TLR4 priming increases TLR2 transcription and expression. In addition, TLR4 priming increases secretion of certain proinflammatory mediators. Expression of costimulatory molecules CD80/CD86 increases with TLR2 or TLR4 activation sequences. Our results reveal that TLR2/TLR4 activation may determine disease pathogenesis and prognosis.

Author information

Author/s: Li, Weixin (W); Gao, Guodong (G); Guo, Qingdong (Q); Jia, Dong (D); Wang, Julei (J); Wang, Xuelian (X); He, Shiming (S); Liang, Qinchuan (Q);

Affiliation: Neurosurgical Department,Tangdu Hospital, Fourth Military Medical University , Xi'an, People's Republic of China .

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: DNA and cell biology (DNA Cell Biol), published in United States. (Language: eng)

Reference: 2009-Oct; vol 28 (issue 10) : pp 493-9

Dates: Created 2009/09/23; Completed 2009/10/26;

PMID: 19622038, status: MEDLINE (last retrieval date: 10/26/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Antigens, CD11b - biosynthesis Antigens, CD18 - biosynthesis Base Sequence DNA Primers Down-Regulation Electrophoretic Mobility Shift Assay Flow Cytometry Histocompatibility Antigens Class II - biosynthesis

Humans Intercellular Adhesion Molecule-1 - biosynthesis Microglia - physiology Phenotype Promoter Regions, Genetic Receptors, IgG - biosynthesis Reverse Transcriptase Polymerase Chain Reaction Toll-Like Receptor 2 - chemistry; genetics; physiology Toll-Like Receptor 4 - chemistry; genetics; physiology

Associated Chemicals: Antigens, CD11b (0) ; Antigens, CD18 (0) ; DNA Primers (0) ; Histocompatibility Antigens Class II (0) ; Receptors, IgG (0) ; TLR2 protein, human (0) ; TLR4 protein, human (0) ; Toll-Like Receptor 2 (0) ; Toll-Like Receptor 4 (0) ; Intercellular Adhesion Molecule-1 (126547-89-5)

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