Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice.

Full Abstract

We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.

Author information

Author/s: Marques, Maria Julia (MJ); Oggiam, Daniella Silva (DS); Barbin, Isabel Cristina Chagas (IC); Ferretti, Renato (R); Santo Neto, Humberto (H);

Affiliation: Departamento de Anatomia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970, Campinas, SP, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Muscle & nerve (Muscle Nerve), published in United States. (Language: eng)

Reference: 2009-Sep; vol 40 (issue 3) : pp 466-8

Dates: Created 2009/08/31; Completed 2009/10/06;

PMID: 19623634, status: MEDLINE (last retrieval date: 10/6/2009, IMS Date: )

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