Biomarkers of oxidative stress in heart failure.

Full Abstract

Oxidative stress is the relative excess of reactive oxygen species (ROS) versus endogenous defense mechanisms. Abundant evidence has demonstrated the role of ROS, along with reactive nitrogen species (RNS), in the pathophysiology of cardiovascular disease, including heart failure. Many biomarkers of oxidative stress have been studied as surrogates of oxidative damage. Recently, markers of impaired nitric oxide signaling have also been identified. Many biomarkers have been associated with prognosis and mortality, and some may even be modified by therapy. However, the clinical utility is limited by less than optimal standardization techniques and the lack of sufficient large-sized, multimarker prospective trials.

Author information

Author/s: Trachtenberg, Barry H (BH); Hare, Joshua M (JM);

Affiliation: University of Miami, Miami, FL 33136, USA.

Grants: R01 AG-025017 (Agency:NIA NIH HHS) ; R01 HL-65455 (Agency:NHLBI NIH HHS) ; R01 HL-HL84275 (Agency:NHLBI NIH HHS) ; R01 U54 HL-81028 (Agency:NHLBI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal: Heart failure clinics (Heart Fail Clin), published in United States. (Language: eng)

Reference: 2009-Oct; vol 5 (issue 4) : pp 561-77

Dates: Created 2009/07/27; Completed 2009/10/28;

PMID: 19631180, status: MEDLINE (last retrieval date: 10/28/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biological Markers - analysis
Heart Failure - diagnosis; metabolism
Hemoglobins - analysis
Humans

Lipoproteins, LDL - analysis; metabolism
Oxidative Stress
Peroxidase - analysis
Uric Acid - analysis

Associated Chemicals: Biological Markers (0) ; Hemoglobins (0) ; Lipoproteins, LDL (0) ; S-nitrosohemoglobin (0) ; Uric Acid (69-93-2) ; Peroxidase (EC 1.11.1.7)

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