Biomarkers of extracellular matrix turnover.

Full Abstract

The extracellular cardiac matrix (ECCM) plays an important role in the support of myocytes and fibroblasts. ECCM turnover is influenced by ischemia, stretch, inflammation, and neurohormonal mediators. Myocardial fibrosis is the consequence of several pathologic processes mediated by mechanical, neurohormonal, and cytokine factors. It is a major determinant of diastolic dysfunction and pumping capacity and may result in tissue heterogeneity, dys-synchrony, and arrhythmias. The measurement of various serum peptides arising from the metabolism of collagen types 1 and 3, of degradation fragments, and of specific metalloproteinases may provide noninvasive assessment of fibrosis. ECCM biomarkers are clinically useful tools, particularly given the potential for cardioprotective and cardioreparative pharmacologic strategies.

Author information

Author/s: Zannad, Faiez (F); Pitt, Bertram (B);

Affiliation: Hôpital Jeanne d'Arc, Dommartin-les-Toul, France.

Journal and publication information

Publication Type: Journal Article

Journal: Heart failure clinics (Heart Fail Clin), published in United States. (Language: eng)

Reference: 2009-Oct; vol 5 (issue 4) : pp 589-99

Dates: Created 2009/07/27; Completed 2009/10/28;

PMID: 19631182, status: MEDLINE (last retrieval date: 10/28/2009, IMS Date: )

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