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| Research article summary (published 30 Jun 2009): |
Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1.
Full Abstract
A series of aromatic aldehydes was examined as substrates for salivary aldehyde dehydrogenase (sALDH) and the recombinant ALDH3A1. Para-substituted benzaldehydes, cinnamic aldehyde and 2-naphthaldehydes were found to be excellent substrates, and kinetic parameters for both salivary and recombinant ALDH were nearly identical. It was demonstrated that for the fluorogenic naphthaldehydes the only produced reaction product after incubation in saliva is the carboxylate.
Author information
Author/s: Giebultowicz, Joanna (J); Wolinowska, Renata (R); Sztybor, Anna (A); Pietrzak, Monika (M); Wroczynski, Piotr (P); Wierzchowski, Jacek (J);
Affiliation: Department of Drugs Analysis, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, PL-02-097, Warsaw, Poland. joanna.giebultowicz(-atsign-)gmail.com
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Molecules (Basel, Switzerland) (Molecules), published in Switzerland. (Language: eng)
Reference: 2009-; vol 14 (issue 7) : pp 2363-72
Dates: Created 2009/07/27; Completed 2009/10/08; Revised 2009/10/27;
PMID: 19633610, status: MEDLINE (last retrieved date: 10/27/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Aldehydes (0) ; Benzaldehydes (0) ; Naphthalenes (0) ; Recombinant Proteins (0) ; 2-naphthaldehyde (66-99-9) ; ALDH3A1 protein, human (EC 1.2.1.3) ; Aldehyde Dehydrogenase (EC 1.2.1.3)Related articles
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