Research article summary (published 2 Aug 2009):

Heart failure in women: a need for prospective data.

Full Abstract

Heart failure affects 5 million Americans, and nearly 50% of these are women. Sex differences have been noted regarding the underlying etiology, pathophysiology, and prognosis. Women are less likely to have coronary artery disease and more likely than men to have hypertension and valvular disease as the underlying etiology. They often present at an older age with better systolic function than men. For both sexes, there is significant morbidity, but age-adjusted data reveal that women have a better survival. Despite these known sex differences, medical management recommendations are the same for women and men, because prospective sex-specific clinical trials have not been performed. However, our review raises some concerns that women might respond differently to therapy.

Author information

Author/s: Hsich, Eileen M (EM); Piña, Ileana L (IL);

Affiliation: Department of Cardiovascular Medicine at the Cleveland Clinic, Cleveland, OH 44195, USA. Hsiche(-atsign-)ccf.org

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Journal of the American College of Cardiology (J Am Coll Cardiol), published in United States. (Language: eng)

Reference: 2009-Aug; vol 54 (issue 6) : pp 491-8

Dates: Created 2009/07/31; Completed 2009/09/15;

PMID: 19643307, status: MEDLINE (last retrieval date: 9/15/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aldosterone Antagonists - therapeutic use Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Cardiac Pacing, Artificial Digoxin - therapeutic use Female Heart Failure - epidemiology; etiology; physiopathology; therapy Heart-Assist Devices Humans

Humans Hydralazine - therapeutic use Isosorbide Dinitrate - therapeutic use Male Pacemaker, Artificial Platelet Aggregation Inhibitors - therapeutic use Risk Factors Sex Factors Women's Health

Associated Chemicals: Aldosterone Antagonists (0) ; Angiotensin II Type 1 Receptor Blockers (0) ; Angiotensin-Converting Enzyme Inhibitors (0) ; Platelet Aggregation Inhibitors (0) ; Digoxin (20830-75-5) ; Hydralazine (86-54-4) ; Isosorbide Dinitrate (87-33-2)

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