A novel function of intestinal gluconeogenesis: central signaling in glucose and energy homeostasis.

Full Abstract

The gut can contribute to the control of glucose homeostasis by its high glycolytic capacity and a recently described function, gluconeogenesis. In addition to its quantitative role in endogenous glucose production, a qualitative role of central signaling was recently described for intestinal gluconeogenesis. Relating to the control of energy homeostasis, intestinal gluconeogenesis, by its detection by a hepatoportal glucose sensor, is able to generate a central signal promoting a decrease in food intake. This mechanism may contribute to the well-known satiety effect initiated by food protein. In relation to the control of glucose homeostasis, intestinal gluconeogenesis has been suggested to be a key factor of the central enhancement of insulin sensitivity for the whole body. It may account for the rapid amelioration of insulin resistance occurring after gastric bypass, a specific type of surgery for morbid obesity. Because these beneficial effects may take place in the context of established physiopathology, they allow one to envision new strategies of prevention or treatment of obesity and type 2 diabetes in humans.

Author information

Author/s: Mithieux, Gilles (G);

Affiliation: Institut National de la Santé et de la Recherche Médicale, U 855, Lyon, France. mithieux(-atsign-)sante.univ-lyon1.fr

Journal and publication information

Publication Type: Journal Article

Journal: Nutrition (Burbank, Los Angeles County, Calif.) (Nutrition), published in United States. (Language: eng)

Reference: 2009-Sep; vol 25 (issue 9) : pp 881-4

Dates: Created 2009/08/03; Completed 2009/10/23;

PMID: 19647621, status: MEDLINE (last retrieved date: 10/23/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.