Research article summary (published 30 Jul 2009):

Goat whey fermentation by Kluyveromyces marxianus and Lactobacillus rhamnosus release tryptophan and tryptophan-lactokinin from a cryptic zone of alpha-lactalbumin.

Full Abstract

Angiotensin-I-Converting Enzyme (ACE) inhibitors peptides were produced from unsupplemented acid goat whey fermented aerobically for 168 h by Kluyveromyces marxianus and Lactobacillus rhamnosus. This yeast-lactobacillus association is GRAS. Two novel lactokinins were identified: NYW and W with IC50 of 20 and 0.86 mum respectively. They both were resistant toward simulated gastrointestinal digestion. In addition, WLAHK was found in the hydrolysate. These three sequences belong to f(99-110) of alpha-la which seems to be a lactokinin cryptic zone. W was the major molecule released by the fermentation process. Considering that W is the precursor of serotonin, the hydrolysate produced could be of interest for the generation of functional health ingredient involved in regulation of affective disorders and hypertension.

Author information

Author/s: Hamme, Vanessa (V); Sannier, Frederic (F); Piot, Jean-Marie (JM); Bordenave-Juchereau, Stephanie (S);

Affiliation: Laboratoire LIENSs, CNRS UMR 6250, site Marie Curie, UFR Sciences Technologies Santé, Avenue Michel Crépeau, F-17042 La Rochelle cedex 01, France. vhamme01(-atsign-)univ-lr.fr

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of dairy research (J Dairy Res), published in England. (Language: eng)

Reference: 2009-Aug; vol 76 (issue 3) : pp 379-83

Dates: Created 2009/08/04; Completed 2009/10/23;

PMID: 19650957, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Angiotensin-Converting Enzyme Inhibitors - isolation & purification; metabolism; pharmacology Animals Female Fermentation Goats Kluyveromyces - metabolism

Kluyveromyces - metabolism Lactalbumin - chemistry; metabolism Lactobacillus rhamnosus - metabolism Milk - metabolism; microbiology Milk Proteins - chemistry; metabolism Tryptophan - metabolism

Associated Chemicals: Angiotensin-Converting Enzyme Inhibitors (0) ; Milk Proteins (0) ; lactokinins (0) ; Tryptophan (73-22-3) ; Lactalbumin (9013-90-5)

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