Research article summary (published 10 Sep 2009):

Serotonin targets inhibitory synapses to induce modulation of network functions.

Full Abstract

The cellular effects of serotonin (5-HT), a neuromodulator with widespread influences in the central nervous system, have been investigated. Despite detailed knowledge about the molecular biology of cellular signalling, it is not possible to anticipate the responses of neuronal networks to a global action of 5-HT. Heterogeneous expression of various subtypes of serotonin receptors (5-HTR) in a variety of neurons differently equipped with cell-specific transmitter receptors and ion channel assemblies can provoke diverse cellular reactions resulting in various forms of network adjustment and, hence, motor behaviour. Using the respiratory network as a model for reciprocal synaptic inhibition, we demonstrate that 5-HT(1A)R modulation primarily affects inhibition through glycinergic synapses. Potentiation of glycinergic inhibition of both excitatory and inhibitory neurons induces a functional reorganization of the network leading to a characteristic change of motor output. The changes in network operation are robust and help to overcome opiate-induced respiratory depression. Hence, 5-HT(1A)R activation stabilizes the rhythmicity of breathing during opiate medication of pain.

Author information

Author/s: Manzke, Till (T); Dutschmann, Mathias (M); Schlaf, Gerald (G); Mörschel, Michael (M); Koch, Uwe R (UR); Ponimaskin, Evgeni (E); Bidon, Olivier (O); Lalley, Peter M (PM); Richter, Diethelm W (DW);

Affiliation: Department of Neuro- and Sensory Physiology, University of Göttingen, , 37073 Göttingen, Germany.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (Philos Trans R Soc Lond B Biol Sci), published in England. (Language: eng)

Reference: 2009-Sep; vol 364 (issue 1529) : pp 2589-602

Dates: Created 2009/08/04; Completed 2009/10/30;

PMID: 19651659, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antibodies, Monoclonal Brain Stem - drug effects; metabolism Buspirone - pharmacology Cats DNA Primers - genetics Efferent Pathways - drug effects; physiology Immunohistochemistry Membrane Potentials - drug effects; physiology Nerve Net - parasitology Periodicity

Phenols - pharmacology Piperazines - pharmacology Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptors, Serotonin - metabolism Respiratory Mechanics - physiology Reverse Transcriptase Polymerase Chain Reaction Serotonin - metabolism Serotonin Agonists - pharmacology Sulfonamides - pharmacology Synapses - drug effects

Associated Chemicals: Antibodies, Monoclonal (0) ; DNA Primers (0) ; Phenols (0) ; Piperazines (0) ; Pyridines (0) ; Receptors, Serotonin (0) ; SB 269970 (0) ; Serotonin Agonists (0) ; Sulfonamides (0) ; WAY 100635 (146714-97-8) ; Buspirone (36505-84-7) ; Serotonin (50-67-9) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)

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