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| Research article summary (published 10 Sep 2009): |
Noeud vital for breathing in the brainstem: gasping--yes, eupnoea--doubtful.
Full Abstract
For the past 200 years, various regions of the brainstem have been proposed as a 'noeud vital' for breathing-a critical region which, when destroyed, results in an irreversible cessation of breathing and death. Complicating this search for a noeud vital is the extensive network of neurons that comprises the brainstem respiratory control system of pons and medulla. Does a cessation of breathing following ablation of any region reflect the removal of a critical set of neurons whose activity generates the respiratory rhythm or does it reflect the interruption of one component of the neuronal circuit, such that this circuit cannot function, at least temporarily? An additional complication is that in contemporary neuroscience, a number of in vitro preparations have been introduced for the study of the generation of the respiratory rhythms. However, how are the rhythms that these preparations generate related to normal breathing? Are these rhythms similar to those of gasping, which is recruited when normal, eupnoeic breathing fails, or are these rhythms unique to the in vitro preparation and not related to any breathing pattern in vivo?
Author information
Author/s: St John, Walter M (WM);
Affiliation: Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, , Lebanon, NH 03756, USA. m.stjhon(-atsign-)dartmouth.edu
Grants: 26091 (Agency:PHS HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review
Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (Philos Trans R Soc Lond B Biol Sci), published in England. (Language: eng)
Reference: 2009-Sep; vol 364 (issue 1529) : pp 2625-33
Dates: Created 2009/08/04; Completed 2009/10/30;
PMID: 19651662, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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