Research article summary (published 4 Aug 2009):

Diversities within genotypes, bioactivity and biosynthetic genes of endophytic actinomycetes isolated from three pharmaceutical plants.

Full Abstract

One hundred and fifty endophytic actinomycetes were isolated from three pharmaceutical plants, Annonaceae squamosal, Camptotheca acuminate and Taxus chinensis. Bioactivity test showed that 72.4% of the endophytic actinomycetes displayed inhibition against more than one indicator microorganism. In total, 9.3 and 10.7% showed the cytotoxicity and antioxidant activity, respectively. 3-Amino-5-hydroxybenzoic acid synthase (AHBA), ketosynthase (KS), cytochrome P450 hydroxylases (CYPs) and epoxidase (ES) encoding genes were found in 8.8, 23.8, 2.8 and 11.7% isolates, respectively, by genes screening. The identification based on traditional and molecular methods indicated that diverse genotypes of Streptomyces were distributed in the three pharmaceutical plants, and a few strains of Amycolatopsis were also found in the root of T. chinensis. These results indicated that endophytic actinomycetes associated with pharmaceutical plants could be a promising source of drug leads.

Author information

Author/s: Wu, Yingying (Y); Lu, Chunhua (C); Qian, Xiaoming (X); Huang, Yaojian (Y); Shen, Yuemao (Y);

Affiliation: The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, PR China. evan1016(-atsign-)yahoo.cn

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Current microbiology (Curr Microbiol), published in United States. (Language: eng)

Reference: 2009-Oct; vol 59 (issue 4) : pp 475-82

Dates: Created 2009/09/04; Completed 2009/11/05;

PMID: 19657693, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Actinobacteria - classification; genetics; isolation & purification; physiology Annonaceae - microbiology Anti-Bacterial Agents - biosynthesis Antioxidants - metabolism Bacterial Proteins - genetics Bacterial Typing Techniques Camptotheca - microbiology Cluster Analysis

DNA, Bacterial - chemistry; genetics DNA, Ribosomal - chemistry; genetics Genetic Variation Molecular Sequence Data Phylogeny RNA, Ribosomal, 16S - genetics Sequence Analysis, DNA Taxus - microbiology

Associated Chemicals: Anti-Bacterial Agents (0) ; Antioxidants (0) ; Bacterial Proteins (0) ; DNA, Bacterial (0) ; DNA, Ribosomal (0) ; RNA, Ribosomal, 16S (0)

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