Research article summary (published 30 Aug 2009):

Association between genetic polymorphism in DNA repair genes and risk of B-cell lymphoma.

Full Abstract

OBJECTIVES: The authors evaluated the possible effect of DNA repair genes, XPD (Xeroderma pigmentosum group D) codon (312 and 751) and XRCC1 (X-ray repair cross-complementing group 1) codon (194 and 399) SNPs (single-nucleotide polymorphisms) on the risk of childhood B-cell lymphoma. METHODS: The polymorphisms were analyzed in 33 patients with BL cases and in 52 healthy, age-matched controls using PCR-RFLP method. RESULTS: The authors observed no association between variation in the XPD codon Asp312Asn, Lys751Gln, and XRCC1 codon Arg399Gln polymorphisms and B-cell lymphoma for any parameter. In contrast, tryptophan allele frequency in control and patient groups was 0.10 and 0.03 respectively (p = .04). The frequency of XRCC1 194Arg/Trp genotype in B-cell lymphoma was significantly lower than that in controls (p = .005). No significant relationship was found between genotypes and stage, lactate dehydrogenase, or bone marrow involvement. CONCLUSIONS: XRCC1 194Trp allele may be associated with a protective effect against development of childhood B-cell lymphoma. However, these results were based on a small number of case and further studies should be done.

Author information

Author/s: Baris, Safa (S); Celkan, Tiraje (T); Batar, Bahadir (B); Guven, Mehmet (M); Ozdil, Mine (M); Ozkan, Alp (A); Apak, Hilmi (H); Yildiz, Inci (I);

Affiliation: Pediatric Hematology and Oncology Department, University of Istanbul, Istanbul, Turkey. safabaris(-atsign-)hotmail.com

Journal and publication information

Publication Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol), published in England. (Language: eng)

Reference: 2009-Sep; vol 26 (issue 6) : pp 467-72

Dates: Created 2009/08/06; Completed 2009/10/27;

PMID: 19657998, status: MEDLINE (last retrieval date: 10/27/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Case-Control Studies Child Codon - genetics DNA Repair - genetics DNA, Neoplasm - genetics DNA-Binding Proteins - genetics Female Humans

Humans Lymphoma, B-Cell - genetics Male Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Risk Factors Xeroderma Pigmentosum Group D Protein - genetics

Associated Chemicals: Codon (0) ; DNA, Neoplasm (0) ; DNA-Binding Proteins (0) ; X-ray repair cross complementing protein 1 (0) ; Xeroderma Pigmentosum Group D Protein (EC 5.99.-)

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