Claudication: exercise vs endoluminal revascularization (CLEVER) study update.

Full Abstract

The Claudication: Exercise vs Endoluminal Revascularization (CLEVER) Study is a prospective multicenter randomized clinical trial designed to compare the relative clinical and cost-effectiveness of invasive revascularization with stents to supervised exercise rehabilitation in a cohort with moderate to severe claudication due to aortoiliac insufficiency. The study is currently enrolling at twenty-eight sites in the US and Canada. Enrollment of 217 participants is planned, with data collected at baseline, six months, and 18 months. The primary study endpoint is maximum walking duration (MWD) on a graded treadmill test; secondary endpoints include community-based walking, markers of cardiovascular disease risk (body mass index, waist circumference, blood pressure, lipid profile, glucose tolerance, and plasma fibrinogen), health-related quality of life, and cost effectiveness. There are currently sixty randomized participants; recruitment is projected to end in July 2010 and final study results reported in June 2012.

Author information

Author/s: Murphy, Timothy P (TP); Hirsch, Alan T (AT); Cutlip, Donald E (DE); Regensteiner, Judith G (JG); Comerota, Anthony J (AJ); Mohler, Emile (E); Cohen, David J (DJ); Massaro, Joseph (J); CLEVER Investigators;

Affiliation: Rhode Island Hospital Vascular Disease Research Center and Brown Medical School Department of Diagnostic Imaging, Providence, RI 02903, USA. tmurphy(-atsign-)lifespan.org

Grants: U01 HL077221 (Agency:NHLBI NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter (J Vasc Surg), published in United States. (Language: eng)

Reference: 2009-Oct; vol 50 (issue 4) : pp 942-945.e2

Dates: Created 2009/09/29; Completed 2009/10/15;

PMID: 19660897, status: MEDLINE (last retrieval date: 10/15/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: J Vasc Surg. 2009 Oct;50(4):945. (PMID: 19786243)

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