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| Research article summary (published Sep 2009): |
Logic networks based on immunorecognition processes.
Full Abstract
The biochemical system logically processing biochemical signals using immune-specific and biocatalytic reactions was designed, and the generated output signals were analyzed by AFM and optical means. Different patterns of immune signals resulted in the formation of various interfacial structures followed by biocatalytic reactions activated by the next set of biochemical inputs. The developed approach to multisignal biosensing allows qualitative evaluation of the biochemical information in terms of YES-NO, providing the base for novel molecular-level logic analysis of complex patterns of biochemical signals. Application of AFM to read out the structures generated on the interface could potentially lead to substantial miniaturization of the immune logic systems.
Author information
Author/s: Strack, Guinevere (G); Chinnapareddy, Soujanya (S); Volkov, Dmytro (D); Halámek, Jan (J); Pita, Marcos (M); Sokolov, Igor (I); Katz, Evgeny (E);
Affiliation: Department of Chemistry and Biomolecular Science, Department of Physics, and Nanoengineering and Biotechnology Laboratories Center (NABLAB), Clarkson University, Potsdam, New York 13699, USA.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal: The journal of physical chemistry. B (J Phys Chem B), published in United States. (Language: eng)
Reference: 2009-Sep; vol 113 (issue 35) : pp 12154-9
Dates: Created 2009/08/27; Completed 2009/10/21;
PMID: 19663516, status: MEDLINE (last retrieval date: 10/21/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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