Diet-dependent net acid load and risk of incident hypertension in United States women.

Full Abstract

Animal and human studies suggest a potential link between acid-base status and blood pressure. Contemporary Western diets yield a daily systemic acid load of varying amounts, yet the association with hypertension has never been explored. We prospectively examined the association between the diet-dependent net acid load (also known as the estimated net endogenous acid production) and the risk of incident hypertension among 87 293 women without a history of hypertension in the Nurses' Health Study II. We also used the ratio of animal protein intake to potassium intake as an alternative evaluation of diet-dependent net acid load. We identified 15 385 incident cases of hypertension during 995 239 person-years of follow-up. After adjusting for potential confounders, women in the top decile of estimated diet-dependent net acid load had an increased risk of hypertension (relative risk: 1.14; 95% CI: 1.05 to 1.24; P for trend=0.01) compared with women in the bottom decile. To test whether the association between estimated diet-dependent net acid load and hypertension is independent of its individual components, an additional adjustment for intakes of protein and potassium was made and resulted in a relative risk of 1.23 (95% CI: 1.08 to 1.41; P for trend=0.003) for the top decile of estimated diet-dependent net acid load. Results of the ratio of animal protein intake to potassium intake were similar with those of estimated diet-depend net acid load. In conclusion, a high diet-dependent net acid load is independently associated with a higher risk of incident hypertension.

Author information

Author/s: Zhang, Luxia (L); Curhan, Gary C (GC); Forman, John P (JP);

Affiliation: Channing Laboratory/Renal Division, Brigham and Women's Hospital, 181 Longwood Ave., Boston, MA 02115, USA. nhlzh(-atsign-)channing.harvard.edu

Grants: CA50385 (Agency:NCI NIH HHS) ; HL079929-01 (Agency:NHLBI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Hypertension (Hypertension), published in United States. (Language: eng)

Reference: 2009-Oct; vol 54 (issue 4) : pp 751-5

Dates: Created 2009/09/17; Completed 2009/10/20;

PMID: 19667248, status: MEDLINE (last retrieved date: 10/20/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Hypertension. 2009 Oct;54(4):698-9. (PMID: 19667255)

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