Research article summary (published 30 Aug 2009):

Exploring clinical characteristics of bipolar depression: internal structure of the bipolar depression rating scale.

Full Abstract

OBJECTIVE: Due to its pleomorphic phenomenology, the clinical features of bipolar depression are difficult to assess. The objective of the present study was therefore to explore the internal structure of the Bipolar Depression Rating Scale (BDRS) in terms of the phenomenological characteristics of bipolar depression. METHODS: Sixty patients with DSM-IV bipolar depression completed the BDRS, depression and excitement subscales of the Positive and Negative Syndrome Scale (PANSS-D and PANSS-E), 17-item Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale, Young Mania Rating Scale (YMRS), and the Drug-Induced Extrapyramidal Symptoms Scale. The internal structure of the BDRS was explored through hierarchical cluster analysis (HCA) using Ward's method and multidimensional scaling (MDS). RESULTS: From 20-item BDRS data, the HCA yielded two symptom clusters. The first cluster included 12 items of conventional depressive symptoms. The second cluster included eight items of mixed symptoms. The MDS identified a depressive-mixed dimension. The depressive symptom cluster showed a more cohesive and conglomerate cluster structure on the MDS map compared to the mixed symptom cluster. After controlling for the effects of treatment-emergent extrapyramidal symptoms, strong positive correlations were observed between the BDRS and other depression rating scales, and the BDRS also weakly correlated with the YMRS and the PANSS-E. CONCLUSIONS: The internal structure of BDRS appears to be sensitive to complex features of bipolar depression. Hence, the BDRS may have an advantage in evaluating clinical changes in patients with bipolar depression within the therapeutic process.

Author information

Author/s: Chang, Jae Seung (JS); Ahn, Yong Min (YM); Yu, Han Young (HY); Park, Hye Jean (HJ); Lee, Kyu Young (KY); Kim, Se Hyun (SH); Kim, Yong Sik (YS);

Affiliation: Department of Neuropsychiatry, Seoul National University Bundang Hospital, Bundang, Seongnam, Gyeonggi, Korea.

Journal and publication information

Publication Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

Journal: The Australian and New Zealand journal of psychiatry (Aust N Z J Psychiatry), published in England. (Language: eng)

Reference: 2009-Sep; vol 43 (issue 9) : pp 830-7

Dates: Created 2009/08/11; Completed 2009/10/21;

PMID: 19670056, status: MEDLINE (last retrieval date: 10/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Antipsychotic Agents - adverse effects Basal Ganglia Diseases - chemically induced Bipolar Disorder - diagnosis Cluster Analysis Cohort Studies

Cohort Studies Female Humans Male Middle Aged Psychiatric Status Rating Scales

Associated Chemicals: Antipsychotic Agents (0)

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