Research article summary (published 13 Nov 2009):

Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients.

Full Abstract

Gastric cancer (GC) is 1 of the most common human cancers. Early detection remains the most promising approach to improving long-term survival of patients with GC. We previously performed Serial Analysis of Gene Expression (SAGE) on 4 primary GCs and identified several GC-specific genes including Reg IV. Of these genes, olfactomedin 4 (OLFM4, also known as GW112 or hGC-1) is a candidate gene for cancer-specific expression. In this study, we examined the expression of olfactomedin 4 in human GC by immunohistochemistry. We also assessed serum olfactomedin 4 levels in GC patients by enzyme-linked immunosorbent assay. 94 (56%) of 167 GC cases were positive for olfactomedin 4 by immunostaining. Olfactomedin 4 staining was observed more frequently in stage I/II cases than in stage III/IV cases. The serum olfactomedin 4 concentration in presurgical GC patients (n = 123, mean +/- SE, 36.3 +/- 3.5 ng/mL) was significantly higher than that in healthy individuals (n = 76, 16.6 +/- 1.6 ng/mL). In patients with stage I GC, the sensitivity of serum olfactomedin 4 (25%) and Reg IV (35%) was superior to that of CA19-9 (5%) or CEA (3%). Furthermore, in patients with stage I GC, the combination of olfactomedin 4 and Reg IV elevated the diagnostic sensitivity to 52%. These results suggest that serum olfactomedin 4 is a useful marker for GC and its measurement alone or in combination with Reg IV has utility in the early detection of GC.

Author information

Author/s: Oue, Naohide (N); Sentani, Kazuhiro (K); Noguchi, Tsuyoshi (T); Ohara, Shinya (S); Sakamoto, Naoya (N); Hayashi, Tetsutaro (T); Anami, Katsuhiro (K); Motoshita, Junichi (J); Ito, Masanori (M); Tanaka, Shinji (S); Yoshida, Kazuhiro (K); Yasui, Wataru (W);

Affiliation: Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2009-Nov; vol 125 (issue 10) : pp 2383-92

Dates: Created 2009/09/28; Completed 2009/11/05;

PMID: 19670418, status: MEDLINE (last retrieval date: 11/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adenocarcinoma - blood; genetics; secondary Adult Aged Aged, 80 and over Animals Blotting, Western CA-19-9 Antigen - blood; genetics Carcinoembryonic Antigen - blood; genetics Carcinoma, Adenosquamous - blood; genetics; secondary Enzyme-Linked Immunosorbent Assay Female Granulocyte Colony-Stimulating Factor - blood; genetics; immunology Humans Immunoenzyme Techniques

Immunoenzyme Techniques Lectins, C-Type - blood; genetics Male Mice Mice, Inbred BALB C Middle Aged Prognosis RNA, Messenger - genetics; metabolism Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Stomach Neoplasms - blood; genetics; pathology Survival Rate Tumor Cells, Cultured Tumor Markers, Biological - blood

Associated Chemicals: CA-19-9 Antigen (0) ; Carcinoembryonic Antigen (0) ; Lectins, C-Type (0) ; OLFM4 protein, human (0) ; REG4 protein, human (0) ; RNA, Messenger (0) ; Tumor Markers, Biological (0) ; Granulocyte Colony-Stimulating Factor (143011-72-7)

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