Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm.

Full Abstract

BACKGROUND: The volatile anesthetics desflurane, isoflurane, and sevoflurane have been found to produce neuroprotection in various paradigms. The authors used these agents in a delayed preconditioning model to test the hypothesis that they could provide neuroprotection against neonatal hypoxia-ischemia as assessed by a battery of behavioral tests. METHODS: Institutional Animal Care and Use Committee approval was obtained. A total of 140, C57-129T2 F1 hybrid 9-day-old mice were randomized to 3 h of preconditioning with room air (Group Sham and Group HI), 8.4% desflurane in 40% oxygen (Group D), 1.8% isoflurane (Group I), or 3.1% sevoflurane (Group S). Twenty-four hours later, the Group HI, D, I, and S mice had 60 min of hypoxia-ischemia, and Group Sham had 60 min of sham HI. Surviving animals had behavioral testing, including open field activity, acoustic startle, prepulse inhibition, rotorod, novel object recognition, water mazes, and apomorphine challenge. Histologic analysis was also performed. RESULTS: Mice in Groups D, I, and S performed better than Group HI and similarly to Group Sham on novel object recognition and apomorphine challenge and better than Group HI but not as well as Group Sham on cued maze testing. All mice exposed to hypoxia-ischemia performed worse than Group Sham on the spatially oriented water mazes with no difference among groups. Histologic sections did not show any significant effect of preconditioning on injury scores. CONCLUSIONS: Volatile agent preconditioning partially protects perirhinal cortex and striatal dependent functions against moderate to severe neonatal hypoxia-ischemia.

Author information

Author/s: McAuliffe, John J (JJ); Loepke, Andreas W (AW); Miles, Lili (L); Joseph, Bernadin (B); Hughes, Elizabeth (E); Vorhees, Charles V (CV);

Affiliation: Department of Anesthesia, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3036, USA. john.mcauliffe(-atsign-)cchmc.org

Journal and publication information

Publication Type: Journal Article

Journal: Anesthesiology (Anesthesiology), published in United States. (Language: eng)

Reference: 2009-Sep; vol 111 (issue 3) : pp 533-46

Dates: Created 2009/08/25; Completed 2009/09/17;

PMID: 19672176, status: MEDLINE (last retrieval date: 9/17/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Anesthetics, Inhalation - therapeutic use
Animals
Animals, Newborn - physiology
Apomorphine - diagnostic use
Behavior, Animal - drug effects
Blood Gas Analysis
Brain - pathology
Cues
Dopamine - physiology
Dopamine Agonists - diagnostic use
Hypoxia-Ischemia, Brain - pathology; prevention & control
Isoflurane - analogs & derivatives; therapeutic use

Isoflurane - analogs & derivatives; therapeutic use
Maze Learning - drug effects
Methyl Ethers - therapeutic use
Mice
Mice, Inbred C57BL
Motor Activity - drug effects
Neuroprotective Agents - pharmacology
Postural Balance - drug effects
Recognition (Psychology) - drug effects
Startle Reaction - drug effects
Treatment Outcome
Weight Gain - drug effects

Associated Chemicals: Anesthetics, Inhalation (0) ; Dopamine Agonists (0) ; Methyl Ethers (0) ; Neuroprotective Agents (0) ; Isoflurane (26675-46-7) ; sevoflurane (28523-86-6) ; desflurane (57041-67-5) ; Apomorphine (58-00-4)

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