Oxygenated lignans from the fruits of Schisandra arisanensis.

Full Abstract

An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A-D (1-4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F-L (5-11), are polyoxygenated C(18)-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated.

Author information

Author/s: Cheng, Yuan-Bin (YB); Chang, Meng-Ting (MT); Lo, Yi-Wen (YW); Ho, Ching-Jen (CJ); Kuo, Yuh-Chi (YC); Chien, Ching-Te (CT); Chen, Shun-Ying (SY); Liou, Shorong-Shii (SS); Kuo, Yao-Haur (YH); Shen, Ya-Ching (YC);

Affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Sec. 1, Taipei 100, Taiwan, Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2009-Sep; vol 72 (issue 9) : pp 1663-8

Dates: Created 2009/09/25; Completed 2009/10/21;

PMID: 19673515, status: MEDLINE (last retrieval date: 10/21/2009, IMS Date: )

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