Research article summary (published 10 Aug 2009):

Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.

Full Abstract

The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [(11)C]DASB [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.

Author information

Author/s: Oler, Jonathan A (JA); Fox, Andrew S (AS); Shelton, Steven E (SE); Christian, Bradley T (BT); Murali, Dhanabalan (D); Oakes, Terrence R (TR); Davidson, Richard J (RJ); Kalin, Ned H (NH);

Affiliation: Departments of Psychiatry, HealthEmotions Research Institute, University of Wisconsin-Madison, 53719, USA.

Grants: MH46729 (Agency:NIMH NIH HHS) ; MH84051 (Agency:NIMH NIH HHS) ; RR000167 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2009-Aug; vol 29 (issue 32) : pp 9961-6

Dates: Created 2009/08/13; Completed 2009/09/08; Revised 2009/10/05;

PMID: 19675230, status: MEDLINE (last retrieval date: 10/6/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amygdala - physiology; radionuclide imaging Aniline Compounds Animals Anxiety - physiopathology; radionuclide imaging Behavior, Animal Female Fluorodeoxyglucose F18 Glucose - metabolism

Linear Models Macaca mulatta Male Positron-Emission Tomography Septal Nuclei - physiology; radionuclide imaging Serotonin Plasma Membrane Transport Proteins - metabolism Sulfides Temperament - physiology

Associated Chemicals: 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile (0) ; Aniline Compounds (0) ; Serotonin Plasma Membrane Transport Proteins (0) ; Sulfides (0) ; Glucose (50-99-7) ; Fluorodeoxyglucose F18 (63503-12-8)

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