Function and biogenesis of iron-sulphur proteins.

Full Abstract

Iron-sulphur (Fe-S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the relative simplicity of Fe-S clusters in terms of structure and composition, their synthesis and assembly into apoproteins is a highly complex and coordinated process in living cells. Different biogenesis machineries in both bacteria and eukaryotes have been discovered that assist Fe-S-protein maturation according to uniform biosynthetic principles. The importance of Fe-S proteins for life is documented by an increasing number of diseases linked to these components and their biogenesis.

Author information

Author/s: Lill, Roland (R);

Affiliation: Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, D-35033 Marburg, Germany. lill(-atsign-)staff.uni-marburg.de

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Nature (Nature), published in England. (Language: eng)

Reference: 2009-Aug; vol 460 (issue 7257) : pp 831-8

Dates: Created 2009/08/13; Completed 2009/09/14;

PMID: 19675643, status: MEDLINE (last retrieval date: 9/14/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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