Effect of experimental hypothyroidism on glomerular filtration rate and plasma creatinine concentration in dogs.

Full Abstract

BACKGROUND: Hypothyroidism affects renal function in a manner opposite the effects of hyperthyroidism. OBJECTIVE: To evaluate the effects of experimentally induced hypothyroidism on glomerular filtration rate (GFR) and basal plasma creatinine concentration in dogs. ANIMALS: Sixteen anestrous, female dogs. METHODS: Hypothyroidism was induced by administration of (131)I in 8 dogs, and 8 healthy euthyroid dogs acted as controls. Exogenous plasma creatinine clearance (an estimate of GFR) was measured in all dogs before (control period) and 43-50 weeks after induction of hypothyroidism (posttreatment period). Other pharmacokinetic parameters of creatinine were also determined. RESULTS: No significant difference was observed for basal plasma creatinine concentration and creatinine clearance between control and hypothyroid dogs in the control period. In the posttreatment period, mean + or - SD creatinine clearance in the hypothyroid group (2.13 + or - 0.48 mL/min/kg) was lower (P < .001) than that of the control group (3.20 + or - 0.42 mL/kg/min). Nevertheless, basal plasma creatinine concentrations were not significantly different between the hypothyroid and control groups (0.74 + or - 0.18 versus 0.70 + or - 0.08 mg/dL, respectively) because endogenous production of creatinine was decreased in hypothyroid dogs (22 + or - 3 versus 32 + or - 5 mg/kg/d, P=.001). CONCLUSION AND CLINICAL IMPORTANCE: Hypothyroidism causes a substantial decrease in GFR without altering plasma creatinine concentrations, indicating that GFR evaluation is needed to identify renal dysfunction in such patients.

Author information

Author/s: Panciera, D L (DL); Lefebvre, H P (HP);

Affiliation: Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA. panciera(-atsign-)vt.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine (J Vet Intern Med), published in United States. (Language: eng)

Reference: -2009 Sep-Oct; vol 23 (issue 5) : pp 1045-50

Dates: Created 2009/09/09; Completed 2009/10/08;

PMID: 19678885, status: MEDLINE (last retrieval date: 10/8/2009, IMS Date: )

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