Retinol-binding protein in serum and urine of hyperthyroid cats before and after treatment with radioiodine.

Full Abstract

BACKGROUND: Retinol-binding protein (RBP) is suggested as a clinically useful marker of renal function in cats. HYPOTHESIS: Serum and urinary RBP concentrations in hyperthyroid (HT) cats differ from those in healthy (H) cats; radioiodine ((131)I) treatment influences serum and urinary RBP concentrations in HT cats. ANIMALS: Ten HT and 8 H cats. METHODS: RBP concentration was evaluated in feline serum and urine samples from a prospective study. RESULTS: There was a significant (P= .003) difference in the urinary RBP/creatinine (uRBP/c) ratios of H (-) and untreated HT (1.4 + or - 1.5 x 10(-2) microg/mg) cats. Serum total thyroxine concentration (1.8 + or - 1.9 microg/dL, 24 weeks) and uRBP/c (0.6 + or - 1.0 x 10(-2) microg/mg, 24 weeks) decreased significantly (P < .001) in HT cats at all time points after treatment with (131)I, and these variables were significantly correlated with one another (r= 0.42, P= .007). Serum RBP concentrations from HT cats (199 + or - 86 microg/L) did not differ significantly (P= .98) from those of H cats (174 + or - 60) and did not change after treatment with (131)I (182 + or - 124 microg/L, P= .80). CONCLUSION AND CLINICAL IMPORTANCE: The presence of urinary RBP in HT cats is a potential marker of tubular dysfunction that is correlated to thyroid status, although it is independent of circulating RBP concentrations. The decreased uRBP/c combined with the absence of changes in serum RBP after treatment suggests that the suspected tubular dysfunction was partly reversible with treatment of (131)I.

Author information

Author/s: van Hoek, I (I); Meyer, E (E); Duchateau, L (L); Peremans, K (K); Smets, P (P); Daminet, S (S);

Affiliation: Department of Medicine & Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. ivanhoek(-atsign-)royal-canin.fr

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine (J Vet Intern Med), published in United States. (Language: eng)

Reference: -2009 Sep-Oct; vol 23 (issue 5) : pp 1031-7

Dates: Created 2009/09/09; Completed 2009/10/08;

PMID: 19678890, status: MEDLINE (last retrieval date: 10/8/2009, IMS Date: )

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