Molecular and serologic markers of acute dengue infection in naive and flavivirus-vaccinated travelers.

Full Abstract

A total of 520 European travelers with suspected dengue fever were examined, and acute dengue virus infection was confirmed in 127 of them. Molecular and serological tests for dengue diagnosis, according to their usefulness in the different stages of the disease, were performed. The accuracy of the IgM/IgG ratio and the IgG avidity index was confirmed during the early phase of the illness to discriminate the serologic status (primary versus secondary immune response) of patients who were either naive or previously vaccinated against other flaviviruses. Virologic markers of secondary infection were detected in 11.8% of nonvaccinated infected patients and in 92.6% of yellow fever vaccinated patients. The proper use of these simple methodologies could help in the identification of patients affected with secondary infection, who may be at a higher risk of developing a hemorrhagic disorder.

Author information

Author/s: Domingo, Cristina (C); de Ory, Fernando (F); Sanz, Juan Carlos (JC); Reyes, Noelia (N); Gascón, Joaquim (J); Wichmann, Ole (O); Puente, Sabino (S); Schunk, Mirjam (M); López-Vélez, Rogelio (R); Ruiz, Joaquim (J); Tenorio, Antonio (A);

Affiliation: Diagnostic Microbiology Service, National Center for Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain. domingo-carrascoc(-atsign-)rki.de

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis), published in United States. (Language: eng)

Reference: 2009-Sep; vol 65 (issue 1) : pp 42-8

Dates: Created 2009/08/14; Completed 2009/10/09;

PMID: 19679234, status: MEDLINE (last retrieval date: 10/9/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antibodies, Viral - blood
Antibody Affinity
Biological Markers
Dengue - diagnosis
Dengue Virus - genetics; immunology
Flavivirus - immunology

Associated Chemicals: Antibodies, Viral (0) ; Biological Markers (0) ; Genetic Markers (0) ; Immunoglobulin G (0) ; Immunoglobulin M (0) ; Viral Vaccines (0)

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