Research article summary (published 30 Aug 2009):

Behavioral and neural correlates of memory selection and interference resolution during a digit working memory task.

Full Abstract

Neuroimaging studies have shown the involvement of prefrontal and posterior parietal cortexes in regulating information processing. We conducted behavioral and fMRI experiments to investigate the relationship between memory selection and proactive interference (PI), using a delayed recognition task with a selection cue presented during the delay indicating which two of the four studied digits were relevant to the present test. PI was indexed by the response time differences between rejecting probes matching and not matching the no longer relevant digits. By varying the delay intervals, we found that the effect of PI did not diminish, even for cases in which the postcue interval was extended to 9 sec, but was stronger when the precue interval was lengthened to 5 sec. By examining the correlation between PI index and neural correlates of memory selection, we found that stronger PI is predicted by lower selection-related activity in the left inferior parietal lobe, the precuneus, and the dorsal middle frontal gyrus. Our results suggest that activity in the prefrontal-parietal network may contribute to one's ability to focus on the task-relevant information and may proactively reduce PI in working memory.

Author information

Author/s: Yi, Yuji (Y); Driesen, Naomi (N); Leung, Hoi-Chung (HC);

Affiliation: Department of Psychology, Stony Brook University, Stony Brook, New York, USA.

Grants: DA024228 (Agency:NIDA NIH HHS) ; R03 DA023044-01A2 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Cognitive, affective & behavioral neuroscience (Cogn Affect Behav Neurosci), published in United States. (Language: eng)

Reference: 2009-Sep; vol 9 (issue 3) : pp 249-59

Dates: Created 2009/08/14; Completed 2009/10/26;

PMID: 19679761, status: MEDLINE (last retrieval date: 10/26/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Analysis of Variance Brain - physiology Brain Mapping Cues Female Humans Linear Models

Magnetic Resonance Imaging Male Memory, Short-Term - physiology Neuropsychological Tests Reaction Time Recognition (Psychology) Time Factors Young Adult

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