[Expression of tissue transglutaminase on renal interstitial fibrosis rats and intervention of GBE]

Full Abstract

OBJECTIVE: To investigate the expression of tissue transglutaminase( tTG) in unilateral ureteral obstruction (UUO) rats and the intervention of Folium Ginkgo (GBE). METHOD: The animal models of unilateral ureteral obstruction (UUO) were used. Wistar rats were randomly divided into four groups, the Sham-operated group, the UUO group, the benazepril (Bena)-treated UUO group and the GBE-treated group. The rats were sacrificed at day 14. Histological changes in renal tubular interstitium were observed with HE and Masson staining, and the mRNA and protein levels of tTG and FN were detected by RT-PCR and immunohistochemistry. RESULT: Compared with the sham group, the expression of tTG and FN were significantly increased (P < 0.01), and decreased after been treated by Bena and GBE (P < 0.05). CONCLUSION: Bena and GBE may suppress the development of fibrosis partially via down-regulation of tTG expression.

Author information

Author/s: Wang, Dan (D); Li, Xiangjun (X); Yu, Xiaoyan (X); Shi, Yan (Y); Yin, Li (L);

Affiliation: Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), published in China. (Language: chi)

Reference: 2009-May; vol 34 (issue 9) : pp 1133-6

Dates: Created 2009/08/18; Completed 2009/10/07;

PMID: 19685752, status: MEDLINE (last retrieval date: 10/7/2009, IMS Date: )

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