Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.

Full Abstract

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4+/-1.4 vs. 3.4+/-1.2 kg; P<0.001) and on body fat percentage loss (4.2+/-0.1 vs. 2.1+/-0.1%; P<0.001) in the combined TT+TC carriers. In contrast, sibutramine caused no significant additional effect on weight loss (P = 0.078) or on body fat percentage loss (P = 0.441) in homozygous C allele carriers.

Author information

Author/s: Hsiao, Dun-Jen (DJ); Wu, Lawrence Shih-Hsin (LS); Huang, Shih-Yi (SY); Lin, Eugene (E);

Affiliation: College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Pharmacogenetics and genomics (Pharmacogenet Genomics), published in United States. (Language: eng)

Reference: 2009-Sep; vol 19 (issue 9) : pp 730-3

Dates: Created 2009/09/04; Completed 2009/10/09;

PMID: 19687782, status: MEDLINE (last retrieval date: 10/9/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adipose Tissue - drug effects
Adolescent
Adult
Aged
Appetite Depressants - therapeutic use
Body Mass Index
Cyclobutanes - therapeutic use
Female
Heterotrimeric GTP-Binding Proteins - genetics

Humans
Male
Middle Aged
Obesity - drug therapy; genetics
Placebos
Polymorphism, Single Nucleotide - genetics
Taiwan
Weight Loss - drug effects; genetics
Young Adult

Associated Chemicals: Appetite Depressants (0) ; Cyclobutanes (0) ; G-protein beta3 subunit (0) ; Placebos (0) ; sibutramine (106650-56-0) ; Heterotrimeric GTP-Binding Proteins (EC 3.6.1.46)

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