Research article summary (published 29 Sep 2009):

Tenascin-C and type I and III collagen expression in total Achilles tendon rupture. An immunohistochemical study.

Full Abstract

Tendon tissue degeneration and changes in collagen composition play a role in spontaneous rupture of the human Achilles tendon. Tenascin-C has been shown to be present in the tissue pathology and changes in tissue loading. We made an immunohistological study of the expression of tenascin-C and type I and III collagens in ruptured human Achilles tendons. METHODS: Three tissue samples in ten individuals, one from the Achilles tendon rupture and two control samples from four and sixteen centimeters proximal in same tendon were collected at surgery. The specimen were fixed and labelled with specific antibodies to type I and III procollagens (PICP, PINP and PIIINP), mature type III collagen (IIINTP) and tenascin-C. The amount of reacting tissue was evaluated visually and graded on a semiquantitative scale. RESULTS: No difference in the expression of tenascin-C was found between the sites. Instead, mature type III collagen content (p=0.008) and type III collagen synthesis (p=0.016) were significantly increased at the rupture site relative to the control site 2. The amount of newly synthesized type I collagen (PINP, PICP) was relatively high at all sites, as expected. CONCLUSION: The expression of type III collagen is increased at the rupture site in the human Achilles tendon, but that of tenascin-C remains unchanged. This finding supports a tissue composition alteration background for Achilles tendon rupture, while the role of mechanical loading at the rupture site remains controversial.

Author information

Author/s: Pajala, Ari (A); Melkko, Jukka (J); Leppilahti, Juhana (J); Ohtonen, Pasi (P); Soini, Ylermi (Y); Risteli, Juha (J);

Affiliation: Division of Orthopaedics, Oulu University Hospital, Oulu, Finland. ari_pajala(-atsign-)mail.suomi.net

Journal and publication information

Publication Type: Journal Article

Journal: Histology and histopathology (Histol Histopathol), published in Spain. (Language: eng)

Reference: 2009-Oct; vol 24 (issue 10) : pp 1207-11

Dates: Created 2009/08/18; Completed 2009/11/03;

PMID: 19688689, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Achilles Tendon - injuries; metabolism Adult Collagen Type I - metabolism Collagen Type III - metabolism Female

Humans Male Middle Aged Rupture - metabolism; pathology Tenascin - metabolism

Associated Chemicals: Collagen Type I (0) ; Collagen Type III (0) ; Tenascin (0)

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