Research article summary (published 30 Dec 2008):

[Receptors involved in the mechanism of action of topical prostaglandines]

(Receptori implicati în mecanismul de actiune al prostaglandinlor topice.)

Full Abstract

Hypotensive effect to prostaglandins analogs (latanoprost, travoprost, tafluprost) means to increase uveoscleral outflow by action to FP receptors who generated extracellular matrix changes and intermuscular spaces changes. Syntetic prostamides analogs (bimatoprost) have a particulary action with a receptors most and intensive studied. The bimatoprost effect is the consequences to preferated stimulations on the specific receptors who have action only the tissue with prostaglandins activity is important to specify what the bimatoprost have dual effect: to uveoscleral outflow and classic outflow by increase hidraulic conductivity.

Author information

Author/s: Neacsu, Alina Mihaela (AM);

Affiliation: Spital Judetean de Urgenta Braila. alinamihaela.neacsu(-atsign-)yahoo.com

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Oftalmologia (Bucharest, Romania : 1990) (Oftalmologia), published in Romania. (Language: rum)

Reference: 2009-; vol 53 (issue 2) : pp 3-7

Dates: Created 2009/08/24; Completed 2009/09/22;

PMID: 19697832, status: MEDLINE (last retrieved date: 9/22/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Amides - administration & dosage; pharmacology Antihypertensive Agents - administration & dosage; pharmacology Cloprostenol - administration & dosage; analogs & derivatives; pharmacology Drug Therapy, Combination Humans Intraocular Pressure - drug effects

Intraocular Pressure - drug effects Ophthalmic Solutions - administration & dosage Prostaglandins - administration & dosage; metabolism; pharmacology Prostaglandins F - administration & dosage; pharmacology Prostaglandins F, Synthetic - administration & dosage; pharmacology Receptors, Prostaglandin - metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Amides (0) ; Antihypertensive Agents (0) ; Ophthalmic Solutions (0) ; Prostaglandins (0) ; Prostaglandins F (0) ; Prostaglandins F, Synthetic (0) ; Receptors, Prostaglandin (0) ; bimatoprost (0) ; prostaglandin F2alpha receptor (0) ; tafluprost (0) ; latanoprost (130209-82-4) ; travoprost (157283-68-6) ; Cloprostenol (40665-92-7)

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