Research article summary (published 30 Aug 2009):

Update on PADI trial: percutaneous transluminal angioplasty and drug-eluting stents for infrapopliteal lesions in critical limb ischemia.

Full Abstract

The Percutaneous transluminal Angioplasty and Drug eluting stents for Infrapopliteal lesions in critical limb ischemia (PADI) trial is a prospective, multicenter, randomized, controlled, double-arm study investigating the safety and efficacy of primary paclitaxel-eluting stent implantation vs primary percutaneous transluminal angioplasty (PTA) in infrapopliteal lesions in critical limb ischemia (CLI). PTA with provisional "bailout" stent implantation is currently an accepted treatment for arterial obstructions in CLI, including those in below-the-knee arteries. A drawback compared to open bypass surgery is the relatively high restenosis rate. One proposed method to reduce restenosis is the use of drug-eluting stents (DES), as these have shown good results in the coronary bed. Primary DES implantation for focal obstructions in infrapopliteal arteries in CLI potentially reduces restenosis compared to PTA alone and may subsequently prolong effect of treatment, allowing for better wound healing, and preventing recurrence of symptoms. In this article, we report on rationale, design, and progress of the PADI trial, which investigates the safety and efficacy of a paclitaxel-eluting stent system compared to PTA with provisional bare metal stent implantation.

Author information

Author/s: Martens, Jasper M (JM); Knippenberg, Bob (B); Vos, Jan-Albert (JA); de Vries, Jean-Paul P (JP); Hansen, Bettina E (BE); van Overhagen, Hans (H); PADI Trial Group;

Affiliation: Department of Radiology, Haga Teaching Hospital, The Hague, The Netherlands. j.m.martens(-atsign-)hagaziekenhuis.nl

Journal and publication information

Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial

Journal: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter (J Vasc Surg), published in United States. (Language: eng)

Reference: 2009-Sep; vol 50 (issue 3) : pp 687-9

Dates: Created 2009/08/24; Completed 2009/09/15;

PMID: 19700099, status: MEDLINE (last retrieval date: 9/15/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: J Vasc Surg. 2009 Sep;50(3):690. (PMID: 19700100)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Angioplasty, Balloon - instrumentation Arterial Occlusive Diseases - complications; diagnosis; therapy Cardiovascular Agents - administration & dosage Constriction, Pathologic Critical Illness Drug-Eluting Stents Humans Ischemia - diagnosis; etiology; therapy Lower Extremity - blood supply Metals

Metals Netherlands Paclitaxel - administration & dosage Popliteal Artery - pathology Prospective Studies Prosthesis Design Recurrence - prevention & control Research Design Stents Treatment Outcome

Associated Chemicals: Cardiovascular Agents (0) ; Metals (0) ; Paclitaxel (33069-62-4)

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