Research article summary (published 30 Aug 2009):

A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state.

Full Abstract

A meta-analysis of neuropsychological studies of patients with bipolar disorder comprised of 42 studies of 1,197 patients in euthymia, 13 studies consisting of 314 patients in a manic/mixed phase of illness, and 5 studies of 96 patients in a depressed state. Cohen d values were calculated for each study as the mean difference between patient and control group score on each neuropsychological measure, expressed in pooled SD units. For euthymia, results revealed impairment across all neuropsychological domains, with d values in the moderate-to-large range (d = .5 - .8) for the vast majority of measures. There was evidence of large effect-size impairment on measures of verbal learning (d = .81), and delayed verbal and nonverbal memory (d = .80 - .92), while effect-size impairment on measures of visuospatial function was small-to-moderate (d

Author information

Author/s: Kurtz, Matthew M (MM); Gerraty, Raphael T (RT);

Affiliation: Department of Psychology and Program in Neuroscience and Behavior, Wesleyan University, Middletown, CT 06459, USA. mkurtz(-atsign-)wesleyan.edu

Grants: K08 MH-69888 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Neuropsychology (Neuropsychology), published in United States. (Language: eng)

Reference: 2009-Sep; vol 23 (issue 5) : pp 551-62

Dates: Created 2009/08/25; Completed 2009/10/16;

PMID: 19702409, status: MEDLINE (last retrieval date: 10/16/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Attention - physiology Bipolar Disorder - complications Cognition Disorders - etiology Confidence Intervals Depression - complications Female Humans MEDLINE - statistics & numerical data

MEDLINE - statistics & numerical data Male Memory, Short-Term - physiology Neuropsychological Tests Odds Ratio Problem Solving - physiology Retrospective Studies Verbal Behavior - physiology

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