Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.

Full Abstract

About 50% of humans with aneurysmal subarachnoid hemorrhage (SAH) die and many survivors have neurological and neurobehavioral dysfunction. Animal studies usually focused on cerebral vasospasm and sometimes neuronal injury. The difference in endpoints may contribute to lack of translation of treatments effective in animals to humans. We reviewed prior animal studies of SAH to determine what neurological and neurobehavioral endpoints had been used, whether they differentiated between appropriate controls and animals with SAH, whether treatment effects were reported and whether they correlated with vasospasm. Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment.

Author information

Author/s: Jeon, Hyojin (H); Ai, Jinglu (J); Sabri, Mohamed (M); Tariq, Asma (A); Shang, Xueyuan (X); Chen, Gang (G); Macdonald, R Loch (RL);

Affiliation: Division of Neurosurgery, St. Michael's Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada. estherhj.jeon(-atsign-)utoronto.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: BMC neuroscience (BMC Neurosci), published in England. (Language: eng)

Reference: 2009-; vol 10 (issue ) : pp 103

Dates: Created 2009/09/24; Completed 2009/10/05;

PMID: 19706182, status: MEDLINE (last retrieval date: 10/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.