MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells.

Full Abstract

The Japanese apricot, known as Ume in Japanese, has been a traditional Japanese medicine for centuries, and is a familiar and commonly consumed food. The health benefits of Ume are now being widely recognized and have been strengthened by recent studies showing that MK615, an extract of compounds from Ume, has strong anticancer and anti-inflammatory effects. However, the potential role of MK615 in the periodontal field remains unknown. Here, we found that MK615 significantly reduced the production of pro-inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) induced by Porphyromonas gingivalis lipopolysaccharide (LPS), a major etiological agent in localized chronic periodontitis, in murine macrophage-like RAW264.7 cells. MK615 markedly inhibited the phosphorylation of ERK1/2, p38MAPK, and JNK, which is associated with pro-inflammatory mediator release pathways. Moreover, MK615 completely blocked LPS-triggered NF-kappaB activation. The present results suggest that MK615 has potential as a therapeutic agent for treating inflammatory diseases such as periodontitis.

Author information

Author/s: Morimoto, Yoko (Y); Kikuchi, Kiyoshi (K); Ito, Takashi (T); Tokuda, Masayuki (M); Matsuyama, Takashi (T); Noma, Satoshi (S); Hashiguchi, Teruto (T); Torii, Mitsuo (M); Maruyama, Ikuro (I); Kawahara, Ko-Ichi (K);

Affiliation: Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun), published in United States. (Language: eng)

Reference: 2009-Nov; vol 389 (issue 1) : pp 90-4

Dates: Created 2009/09/23; Completed 2009/10/08;

PMID: 19706286, status: MEDLINE (last retrieved date: 10/8/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Active Transport, Cell Nucleus
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology; therapeutic use
Cell Line
Interleukin-6 - antagonists & inhibitors; biosynthesis
Lipopolysaccharides - immunology
Macrophages - drug effects; enzymology

Mice
Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors
Periodontitis - drug therapy; microbiology
Plant Extracts - pharmacology; therapeutic use
Porphyromonas gingivalis
Transcription Factor RelA - metabolism
Tumor Necrosis Factor-alpha - antagonists & inhibitors; biosynthesis

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Anti-Inflammatory Agents, Non-Steroidal (0) ; Interleukin-6 (0) ; Lipopolysaccharides (0) ; MK615 extract (0) ; Plant Extracts (0) ; Rela protein, mouse (0) ; Transcription Factor RelA (0) ; Tumor Necrosis Factor-alpha (0) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.1.-)

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