Oenanthe javanica extract accelerates ethanol metabolism in ethanol-treated animals.

Full Abstract

The effect of water dropwort (Oenanthe javanica DC) extract in eliminating ethanol was evaluated in New Zealand white rabbit and ICR mice. When a hot-water extract of water dropwort extract and ethanol was injected into New Zealand white rabbit, the plasma ethanol level was rapidly reduced, similar to metadoxine treatment. Specifically, the n-butanol fraction of hot-water extract was the strongest in eliminating plasma alcohol in ICR mice. When ethanol was orally ingested, administration of the hot-water extract eliminated up to 44% of the plasma ethanol in mice while the n-butanol fraction eliminated around 70%. Alcohol removal behaved in a dose-dependent manner in response to 50-200 mg/kg of n-butanol fraction. These data show O. javanica extract is effective in overcoming alcohol intoxication by the accelerating ethanol metabolism.

Author information

Author/s: Kim, Jong Yeon (JY); Kim, Ki-Hoon (KH); Lee, Youn Ju (YJ); Lee, Seung Ho (SH); Park, Jong Cheol (JC); Nam, Doo Hyun (DH);

Affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BMB reports (BMB Rep), published in Korea (South). (Language: eng)

Reference: 2009-Aug; vol 42 (issue 8) : pp 482-5

Dates: Created 2009/08/28; Completed 2009/09/28;

PMID: 19712583, status: MEDLINE (last retrieved date: 9/28/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.