Oenanthe javanica extract accelerates ethanol metabolism in ethanol-treated animals.

Full Abstract

The effect of water dropwort (Oenanthe javanica DC) extract in eliminating ethanol was evaluated in New Zealand white rabbit and ICR mice. When a hot-water extract of water dropwort extract and ethanol was injected into New Zealand white rabbit, the plasma ethanol level was rapidly reduced, similar to metadoxine treatment. Specifically, the n-butanol fraction of hot-water extract was the strongest in eliminating plasma alcohol in ICR mice. When ethanol was orally ingested, administration of the hot-water extract eliminated up to 44% of the plasma ethanol in mice while the n-butanol fraction eliminated around 70%. Alcohol removal behaved in a dose-dependent manner in response to 50-200 mg/kg of n-butanol fraction. These data show O. javanica extract is effective in overcoming alcohol intoxication by the accelerating ethanol metabolism.

Author information

Author/s: Kim, Jong Yeon (JY); Kim, Ki-Hoon (KH); Lee, Youn Ju (YJ); Lee, Seung Ho (SH); Park, Jong Cheol (JC); Nam, Doo Hyun (DH);

Affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BMB reports (BMB Rep), published in Korea (South). (Language: eng)

Reference: 2009-Aug; vol 42 (issue 8) : pp 482-5

Dates: Created 2009/08/28; Completed 2009/09/28;

PMID: 19712583, status: MEDLINE (last retrieval date: 9/28/2009, IMS Date: )

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