Research article summary (published 29 Aug 2009):

Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage.

Full Abstract

Anti-oxidative effect of Phellinus linteus (P. linteus) and red ginseng extracts on DNA damage induced by reactive oxygen species (ROS) were investigated in this study. P. linteus (PLE) and red ginseng extracts (RGE) inhibited the breaking of E. coli ColE1 plasmid DNA strands as well as nuclear DNA of rat hepatocytes damaged by oxidative stress. In addition, a reaction mixture of PLE and RGE showed synergistic inhibitory effect against DNA damage. These results suggest that PLE and RGE have a cellular defensive effect against DNA damage induced by ROS.

Author information

Author/s: Park, Byung-Jae (BJ); Lim, Yeong-Seok (YS); Lee, Hee-Jung (HJ); Eum, Won Sik (WS); Park, Jinseu (J); Han, Kyu Hyung (KH); Choi, Soo Young (SY); Lee, Kil Soo (KS);

Affiliation: Department of Life Science, Hallym University, Chunchon 202-702, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BMB reports (BMB Rep), published in Korea (South). (Language: eng)

Reference: 2009-Aug; vol 42 (issue 8) : pp 500-5

Dates: Created 2009/08/28; Completed 2009/09/28;

PMID: 19712586, status: MEDLINE (last retrieval date: 9/28/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antioxidants - pharmacology Cell Nucleus - drug effects; metabolism DNA Breaks - drug effects DNA Damage DNA, Bacterial - metabolism Eukaryotic Cells - drug effects; metabolism Ferrous Compounds - pharmacology

Hepatocytes - drug effects; metabolism Hydrogen Peroxide - pharmacology Oxidative Stress - drug effects Panax - metabolism Plant Extracts - pharmacology Plasmids - metabolism Polysaccharides - pharmacology Rats

Associated Chemicals: Antioxidants (0) ; DNA, Bacterial (0) ; Ferrous Compounds (0) ; Phellinus linteus extract (0) ; Plant Extracts (0) ; Polysaccharides (0) ; Hydrogen Peroxide (7722-84-1) ; ferrous chloride (7758-94-3)

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