Research article summary (published 30 Aug 2009):

Applications of magnetic nanoparticles in medicine: magnetic fluid hyperthermia.

Full Abstract

Nanoparticle systems are an intense subject of research for various biomedical applications. Colloidal suspensions of magnetic nanoparticles are of special interest, particularly in bioimaging, and more recently, in Magnetic Fluid Hyperthermia (MFH). MFH promises to be a viable alternative in the treatment of localized cancerous tumors. The treatment consists of locally injecting magnetic nanoparticles in fluid suspension into the tumor site and exposing the site to an oscillating magnetic field, where nanoparticles dissipate energy in the form of heat, causing a localized rise in temperature and tumor cell death. Here we will review methods of magnetic nanoparticle synthesis, and the role of the nanoparticle surface coating in achieving colloidal stability, minimizing toxicity, and targeting. Finally, we review in vitro and in vivo MFH experiments, and clinical studies in the treatment of glioblastoma multiforme and prostate cancer.

Author information

Author/s: Latorre, Magda (M); Rinaldi, Carlos (C);

Affiliation: Department of Chemical Engineering, University of Puerto Rico, Mayagüez.

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review

Journal: Puerto Rico health sciences journal (P R Health Sci J), published in Puerto Rico. (Language: eng)

Reference: 2009-Sep; vol 28 (issue 3) : pp 227-38

Dates: Created 2009/08/31; Completed 2009/10/26;

PMID: 19715115, status: MEDLINE (last retrieved date: 10/26/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Humans Hyperthermia, Induced - methods

Hyperthermia, Induced - methods Magnetics Nanoparticles

Note: Bold headings indicate primary MeSH headings or qualifiers.

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