Research article summary (published 30 Aug 2009):

The association between cardiorespiratory fitness and risk of all-cause mortality among women with impaired fasting glucose or undiagnosed diabetes mellitus.

Full Abstract

OBJECTIVE: To evaluate the independent and joint associations among cardiorespiratory fitness (CRF), body mass index, and risk of mortality from any cause among women with impaired fasting glucose (IFG) or undiagnosed diabetes mellitus (DM). PATIENTS AND METHODS: Female patients (N=3044; mean age, 47.4 years) with IFG or undiagnosed DM completed a maximal exercise treadmill test (between January 26, 1971, and March 21, 2001). The women had no history of a cardiovascular disease event or diagnosed DM at baseline. Cardiorespiratory fitness was defined categorically as low (bottom 20%), moderate (middle 40%), or high (upper 40%) according to previously published Aerobics Center Longitudinal Study guidelines. Body mass index was calculated as the weight in kilograms divided by the height in meters squared (kg/m(2)). RESULTS: During a 16-year follow-up period, 171 deaths occurred. There was an inverse association between CRF and all-cause mortality risk. Women with moderate or high CRF were at lower risk of mortality (moderate CRF, 35% lower; high CRF, 36% lower; P(trend)=.03) than those with low CRF. An exercise capacity lower than 7 metabolic equivalents was associated with a 1.5-fold higher risk of death than an exercise capacity of 9 metabolic equivalents or higher (P(trend)=.05). The multivariate adjusted hazard ratios (HRs), including adjustments for CRF, were higher for heavier patients than for patients of normal weight (overweight patients: HR, 0.86; 95% confidence interval, 0.57-1.30; obese patients: HR, 1.19; 95% confidence interval, 0.70-2.03; P(trend)=.84). Combined analyses showed that women who were overweight or obese and unfit (low CRF) were at more than twice the risk of death than women who were of normal weight and fit (moderate or high CRF). CONCLUSION: Cardiorespiratory fitness, not body mass index, is a significant predictor of all-cause mortality among women with IFG or undiagnosed DM. Assessing CRF levels provides important prognostic information independent of traditional risk factors.

Author information

Author/s: Lyerly, G William (GW); Sui, Xuemei (X); Lavie, Carl J (CJ); Church, Timothy S (TS); Hand, Gregory A (GA); Blair, Steven N (SN);

Affiliation: Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, USA. glyerly(-atsign-)coastal.edu

Grants: AG06945 (Agency:NIA NIH HHS) ; HL62508 (Agency:NHLBI NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Mayo Clinic proceedings. Mayo Clinic (Mayo Clin Proc), published in United States. (Language: eng)

Reference: 2009-Sep; vol 84 (issue 9) : pp 780-6

Dates: Created 2009/09/01; Completed 2009/09/21;

PMID: 19720775, status: MEDLINE (last retrieval date: 9/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Mayo Clin Proc. 2009 Sep;84(9):776-9. (PMID: 19720774)

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Blood Glucose - metabolism Body Mass Index Cardiovascular Physiological Phenomena Diabetes Mellitus - blood; physiopathology Exercise Test Fasting Female Humans

Humans Longitudinal Studies Middle Aged Mortality Overweight - physiopathology Physical Fitness Proportional Hazards Models Respiratory Physiological Phenomena Risk Factors Young Adult

Associated Chemicals: Blood Glucose (0)

Related articles

These are the highest related articles currently in the database:

• [Centripetal distribution of body fat, overweight and cardiorespiratory fitness: association with insulin sensitivity and metabolic alterations] 29 Nov 2006
• Cardiorespiratory fitness and body mass index of 9-11-year-old English children: a serial cross-sectional study from 1998 to 2004. 18 Feb 2007
• Cardiorespiratory fitness predicts changes in adiposity in overweight Hispanic boys. 26 Feb 2008
• Physical activity patterns associated with cardiorespiratory fitness and reduced mortality: the Aerobics Center Longitudinal Study. 29 Nov 1998
• Body composition and cardiorespiratory fitness among refugee Somali women living in New Zealand. 29 Jun 2007
• Effects of detraining on the functional capacity of previously trained breast cancer survivors. 14 Nov 2006
• Combined influence of cardiorespiratory fitness and body mass index on cardiovascular disease risk factors among 8-18 year old youth: The Aerobics Center Longitudinal Study. 30 Dec 2006
• Exercise testing and training of the elderly patient. 30 Dec 1984
• Longitudinal changes in cardiorespiratory fitness: measurement error or true change? 29 Jun 2004
• Circulo-respiratory fitness in United States Air Force Academy cadets. 30 Aug 1975

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.