Research article summary (published 30 Aug 2009):

Tendon re-attachment to metal prostheses in an in vivo animal model using demineralised bone matrix.

Full Abstract

We used demineralised bone matrix (DBM) to augment re-attachment of tendon to a metal prosthesis in an in vivo ovine model of reconstruction of the extensor mechanism at the knee. We hypothesised that augmentation of the tendon-implant interface with DBM would enhance the functional and histological outcomes as compared with previously reported control reconstructions without DBM. Function was assessed at six and 12 weeks postoperatively, and histological examination was undertaken at 12 weeks. A significant increase of 23.5% was observed in functional weight-bearing at six weeks in the DBM-augmented group compared with non-augmented controls (p = 0.004). By 12 weeks augmentation with DBM resulted in regeneration of a more direct-type enthesis, with regions of fibrocartilage, mineralised fibrocartilage and bone. In the controls the interface was predominantly indirect, with the tendon attached to the bone graft-hydroxyapatite base plate by perforating collagen fibres.

Author information

Author/s: Sundar, S (S); Pendegrass, C J (CJ); Oddy, M J (MJ); Blunn, G W (GW);

Affiliation: Centre for Biomedical Engineering, Institute of Orthopaedics and Musculoskeletal Science Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK. c.pendegrass(-atsign-)ucl.ac.uk

Journal and publication information

Publication Type: Journal Article

Journal: The Journal of bone and joint surgery. British volume (J Bone Joint Surg Br), published in England. (Language: eng)

Reference: 2009-Sep; vol 91 (issue 9) : pp 1257-62

Dates: Created 2009/09/01; Completed 2009/09/18;

PMID: 19721058, status: MEDLINE (last retrieval date: 9/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Biomechanics Bone Matrix - surgery Knee Joint - surgery

Prosthesis Design Sheep Tendons - surgery Weight-Bearing - physiology

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