Research article summary (published 30 Oct 2009):

Tonabersat, a novel gap-junction modulator for the prevention of migraine.

Full Abstract

Migraine is a common, recurrent, primary headache disorder associated with significant morbidity as well as high direct and indirect costs. Despite its impact, only a proportion of migraineurs who meet criteria for prophylactic treatment take preventive medication. Antiepileptic drugs and beta-blockers are among the most used preventive therapies, but their exact mechanisms of action in migraine prophylaxis are unknown. Recent research has pointed to the role of cortical spreading depression in the genesis of migraine aura and pain, with neuronal-glial gap junctions playing a prominent part in cortical spreading depression. Tonabersat is a unique compound with demonstrated activity as a gap-junction inhibitor in animal studies. In preclinical and clinical trials, tonabersat was well tolerated, with no cardiovascular effects; the pharmacokinetic profile suggested its usefulness in the prophylaxis of migraine.

Author information

Author/s: Silberstein, S D (SD);

Affiliation: Jefferson Headache Center, Philadelphia, PA 19107, USA. stephen.silberstein(-atsign-)jefferson.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Cephalalgia : an international journal of headache (Cephalalgia), published in England. (Language: eng)

Reference: 2009-Nov; vol 29 Suppl 2 (issue ) : pp 28-35

Dates: Created 2009/09/02; Completed 2009/11/17;

PMID: 19723123, status: MEDLINE (last retrieved date: 11/17/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Analgesics - pharmacology Animals Benzamides - pharmacology Benzopyrans - pharmacology Brain - drug effects Clinical Trials as Topic

Clinical Trials as Topic Gap Junctions - drug effects Guidelines as Topic Humans Migraine Disorders - drug therapy Spreading Cortical Depression - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Analgesics (0) ; Benzamides (0) ; Benzopyrans (0) ; tonabersat (175013-84-0)

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