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| Research article summary (published 29 Aug 2009): |
The emerging roles of serine protease cascades in the epidermis.
Full Abstract
It has become clear in recent years that serine proteases have an important role in epidermal homeostasis, and the signaling cascades are gradually being identified. For example, matriptase, prostasin and furin are implicated in a cascade that could activate ENaC, leading to epidermal barrier formation and hydration, probably in part through their involvement in filaggrin processing. Kallikreins can form a signaling cascade to coordinate corneocyte desquamation. Knowledge is also emerging about how endogenous inhibitors, calcium and pH control these cascades. It is becoming clear that some skin pathologies are associated with deregulated serine protease activity. Therefore, a deeper knowledge of the regulation of these serine protease cascades could form the basis for development of appropriate treatments for skin disorders such as Netherton syndrome.
Author information
Author/s: Ovaere, Petra (P); Lippens, Saskia (S); Vandenabeele, Peter (P); Declercq, Wim (W);
Affiliation: Department of Biomedical Molecular Biology, Ghent University, Belgium.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Trends in biochemical sciences (Trends Biochem Sci), published in England. (Language: eng)
Reference: 2009-Sep; vol 34 (issue 9) : pp 453-63
Dates: Created 2009/09/14; Completed 2009/10/16;
PMID: 19726197, status: MEDLINE (last retrieval date: 10/16/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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