When DNA replication and protein synthesis come together.

Full Abstract

In all organisms, DNA and protein are synthesized by dedicated, but unrelated, machineries that move along distinct templates with no apparent coordination. Therefore, connections between DNA replication and translation are a priori unexpected. However, recent findings support the existence of such connections throughout the three domains of life. In particular, we recently identified in archaeal genomes a conserved association between genes encoding DNA replication and ribosome-related proteins which all have eukaryotic homologs. We believe that this gene organization is biologically relevant and, moreover, that it suggests the existence of a mechanism coupling DNA replication and translation in Archaea and Eukarya.

Author information

Author/s: Berthon, Jonathan (J); Fujikane, Ryosuke (R); Forterre, Patrick (P);

Affiliation: Université Paris-Sud 11, CNRS UMR 8621, Institut de Génétique et Microbiologie, 91405 Orsay Cedex, France. jonathan.berthon(-atsign-)gmx.fr

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Trends in biochemical sciences (Trends Biochem Sci), published in England. (Language: eng)

Reference: 2009-Sep; vol 34 (issue 9) : pp 429-34

Dates: Created 2009/09/14; Completed 2009/10/16;

PMID: 19729310, status: MEDLINE (last retrieval date: 10/16/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Associated Chemicals: Bacterial Proteins (0) ; Obg GTP-binding protein, Bacteria (0) ; Guanosine Tetraphosphate (33503-72-9) ; Guanosine Pentaphosphate (38918-96-6) ; GTP Phosphohydrolases (EC 3.6.1.-) ; GTP-Binding Proteins (EC 3.6.1.-)

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